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SbcC-SbcD and ExoI process convergent forks to complete chromosome replication

SbcC-SbcD are the bacterial orthologs of Mre11-Rad50, a nuclease complex essential for genome stability, normal development, and viability in mammals. In vitro, these enzymes degrade long DNA palindromic structures. When inactivated along with ExoI in Escherichia coli, or Sae2 in eukaryotes, palindr...

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Publicat a:Proc Natl Acad Sci U S A
Autors principals: Wendel, Brian M., Cole, Jessica M., Courcelle, Charmain T., Courcelle, Justin
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2018
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5777064/
https://ncbi.nlm.nih.gov/pubmed/29208713
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1715960114
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