The prodrug of 7,8-dihydroxyflavone development and therapeutic efficacy for treating Alzheimer’s disease

The BDNF mimetic compound 7,8-dihydroxyflavone (7,8-DHF), a potent small molecular TrkB agonist, displays prominent therapeutic efficacy against Alzheimer’s disease (AD). However, 7,8-DHF has only modest oral bioavailability and a moderate pharmacokinetic (PK) profile. To alleviate these preclinical...

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Dettagli Bibliografici
Pubblicato in:Proc Natl Acad Sci U S A
Autori principali: Chen, Chun, Wang, Zhihao, Zhang, Zhentao, Liu, Xia, Kang, Seong Su, Zhang, Ying, Ye, Keqiang
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2018
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5777001/
https://ncbi.nlm.nih.gov/pubmed/29295929
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1718683115
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