7,8-Dihydroxyflavone Prevents Synaptic Loss and Memory Deficits in a Mouse Model of Alzheimer's Disease

Synaptic loss in the brain correlates well with disease severity in Alzheimer disease (AD). Deficits in brain-derived neurotrophic factor/tropomyosin-receptor-kinase B (TrkB) signaling contribute to the synaptic dysfunction of AD. We have recently identified 7,8-dihydroxyflavone (7,8-DHF) as a poten...

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Detalhes bibliográficos
Main Authors: Zhang, Zhentao, Liu, Xia, Schroeder, Jason P, Chan, Chi-Bun, Song, Mingke, Yu, Shan Ping, Weinshenker, David, Ye, Keqiang
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2014
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3895241/
https://ncbi.nlm.nih.gov/pubmed/24022672
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/npp.2013.243
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