Optimization of a Small Tropomyosin-related Kinase B (TrkB) Agonist 7,8-Dihydroxyflavone Active in Mouse Models of Depression

Structure-activity relationship study shows that the catechol group in 7,8-dihdyroxyflavone, a selective small TrkB receptor agonist, is critical for the agonistic activity. To improve the poor pharmacokinetic profiles intrinsic to catechol-containing molecules and elevate the agonistic effect of th...

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Detaylı Bibliyografya
Asıl Yazarlar: Liu, Xia, Chan, Chi-Bun, Qi, Qi, Xiao, Ge, Luo, Hongbo R., He, Xiaolin, Ye, Keqiang
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2012
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3491656/
https://ncbi.nlm.nih.gov/pubmed/22984948
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm301099x
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