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Silk-based multilayered angle-ply annulus fibrosus construct to recapitulate form and function of the intervertebral disc

Recapitulation of the form and function of complex tissue organization using appropriate biomaterials impacts success in tissue engineering endeavors. The annulus fibrosus (AF) represents a complex, multilamellar, hierarchical structure consisting of collagen, proteoglycans, and elastic fibers. To m...

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Pubblicato in:Proc Natl Acad Sci U S A
Autori principali: Bhunia, Bibhas K., Kaplan, David L., Mandal, Biman B.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2018
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5776988/
https://ncbi.nlm.nih.gov/pubmed/29282316
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1715912115
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