C-terminal modification of the insulin B:11–23 peptide creates superagonists in mouse and human type 1 diabetes

A polymorphism at β57 in some major histocompatibility complex class II (MHCII) alleles of rodents and humans is associated with a high risk for developing type 1 diabetes (T1D). However, a highly diabetogenic insulin B chain epitope within the B:9–23 peptide is presented poorly by these alleles to...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Wang, Yang, Sosinowski, Tomasz, Novikov, Andrey, Crawford, Frances, Neau, David B., Yang, Junbao, Kwok, William W., Marrack, Philippa, Kappler, John W., Dai, Shaodong
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2018
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5776820/
https://ncbi.nlm.nih.gov/pubmed/29255035
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1716527115
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