Prognostic and predictive role of EGFR pathway alterations in biliary cancer patients treated with chemotherapy and anti-EGFR

The association of anti-EGFR to gemcitabine and oxaliplatin (GEMOX) chemotherapy did not improve survival in biliary tract carcinoma (BTC) patients. Multiple mechanisms might be involved in the resistance to anti-EGFR. Here, we explored the mutation profile of EGFR extracellular domain (ECD), of tyr...

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Veröffentlicht in:PLoS One
Hauptverfasser: Peraldo-Neia, Caterina, Cavalloni, Giuliana, Fenocchio, Elisabetta, Cagnazzo, Celeste, Gammaitoni, Loretta, Cereda, Stefano, Nasti, Guglielmo, Satolli, Maria Antonietta, Aprile, Giuseppe, Reni, Michele, Avallone, Antonio, Spadi, Rosella, Venesio, Tiziana, Martin, Vittoria, Doglioni, Claudio, Frattini, Milo, Aglietta, Massimo, Leone, Francesco
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2018
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5774843/
https://ncbi.nlm.nih.gov/pubmed/29352306
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0191593
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