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An Ichor-dependent apical extracellular matrix regulates seamless tube shape and integrity

During sprouting angiogenesis in the vertebrate vascular system, and primary branching in the Drosophila tracheal system, specialized tip cells direct branch outgrowth and network formation. When tip cells lumenize, they form subcellular (seamless) tubes. How these seamless tubes are made, shaped an...

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Veröffentlicht in:PLoS Genet
Hauptverfasser: Rosa, Jeffrey B., Metzstein, Mark M., Ghabrial, Amin S.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2018
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5774827/
https://ncbi.nlm.nih.gov/pubmed/29309404
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1007146
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