Dexmedetomidine reduces lipopolysaccharide induced neuroinflammation, sickness behavior, and anhedonia

BACKGROUND: Peripheral innate immune response may induce sickness behavior through activating microglia, excessive cytokines production, and neuroinflammation. Dexmedetomidine (Dex) has anti-inflammatory effect. We investigated the effects of Dex on lipopolysaccharide (LPS)-induced neuroinflammation...

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Dettagli Bibliografici
Pubblicato in:PLoS One
Autori principali: Yeh, Ching-Hua, Hsieh, Liang-Po, Lin, Ming-Chung, Wei, Tsui-Shan, Lin, Hui-Ching, Chang, Chia-Cheng, Hsing, Chung-Hsi
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2018
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5774758/
https://ncbi.nlm.nih.gov/pubmed/29351316
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0191070
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