Interactions of 2’-O-methyl oligoribonucleotides with the RNA models of the 30S subunit A-site

Synthetic oligonucleotides targeting functional regions of the prokaryotic rRNA could be promising antimicrobial agents. Indeed, such oligonucleotides were proven to inhibit bacterial growth. 2’-O-methylated (2’-O-Me) oligoribonucleotides with a sequence complementary to the decoding site in 16S rRN...

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Udgivet i:PLoS One
Main Authors: Jasiński, Maciej, Kulik, Marta, Wojciechowska, Monika, Stolarski, Ryszard, Trylska, Joanna
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2018
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5774723/
https://ncbi.nlm.nih.gov/pubmed/29351348
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0191138
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