Oxidative stress via inhibition of the mitochondrial electron transport and Nrf-2-mediated anti-oxidative response regulate the cytotoxic activity of plumbagin

Plumbagin, an anti-cancer agent, is toxic to cells of multiple species. We investigated if plumbagin targets conserved biochemical processes. Plumbagin induced DNA damage and apoptosis in cells of diverse mutational background with comparable potency. A 3–5 fold increase in intracellular oxygen radi...

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Bibliografiske detaljer
Udgivet i:Sci Rep
Main Authors: Kapur, Arvinder, Beres, Thomas, Rathi, Kavya, Nayak, Amruta P., Czarnecki, Austin, Felder, Mildred, Gillette, Amani, Ericksen, Spencer S., Sampene, Emmanuel, Skala, Melissa C., Barroilhet, Lisa, Patankar, Manish S.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5773707/
https://ncbi.nlm.nih.gov/pubmed/29348410
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-19261-w
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