Customised in vitro model to detect human metabolism-dependent idiosyncratic drug-induced liver injury

Drug-induced liver injury (DILI) has a considerable impact on human health and is a major challenge in drug safety assessments. DILI is a frequent cause of liver injury and a leading reason for post-approval drug regulatory actions. Considerable variations in the expression levels of both cytochrome...

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Detalles Bibliográficos
Publicado en:Arch Toxicol
Main Authors: Tolosa, Laia, Jiménez, Nuria, Pérez, Gabriela, Castell, José V., Gómez-Lechón, M. José, Donato, M. Teresa
Formato: Artigo
Idioma:Inglês
Publicado: Springer Berlin Heidelberg 2017
Assuntos:
Organ Toxicity and Mechanisms
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5773651/
https://ncbi.nlm.nih.gov/pubmed/28762043
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00204-017-2036-4
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