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Customised in vitro model to detect human metabolism-dependent idiosyncratic drug-induced liver injury
Drug-induced liver injury (DILI) has a considerable impact on human health and is a major challenge in drug safety assessments. DILI is a frequent cause of liver injury and a leading reason for post-approval drug regulatory actions. Considerable variations in the expression levels of both cytochrome...
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| 發表在: | Arch Toxicol |
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| Main Authors: | , , , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
Springer Berlin Heidelberg
2017
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5773651/ https://ncbi.nlm.nih.gov/pubmed/28762043 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00204-017-2036-4 |
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