Identification of genetic elements in metabolism by high-throughput mouse phenotyping

Metabolic diseases are a worldwide problem but the underlying genetic factors and their relevance to metabolic disease remain incompletely understood. Genome-wide research is needed to characterize so-far unannotated mammalian metabolic genes. Here, we generate and analyze metabolic phenotypic data...

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Vydáno v:Nat Commun
Hlavní autoři: Rozman, Jan, Rathkolb, Birgit, Oestereicher, Manuela A., Schütt, Christine, Ravindranath, Aakash Chavan, Leuchtenberger, Stefanie, Sharma, Sapna, Kistler, Martin, Willershäuser, Monja, Brommage, Robert, Meehan, Terrence F., Mason, Jeremy, Haselimashhadi, Hamed, Hough, Tertius, Mallon, Ann-Marie, Wells, Sara, Santos, Luis, Lelliott, Christopher J., White, Jacqueline K., Sorg, Tania, Champy, Marie-France, Bower, Lynette R., Reynolds, Corey L., Flenniken, Ann M., Murray, Stephen A., Nutter, Lauryl M. J., Svenson, Karen L., West, David, Tocchini-Valentini, Glauco P., Beaudet, Arthur L., Bosch, Fatima, Braun, Robert B., Dobbie, Michael S., Gao, Xiang, Herault, Yann, Moshiri, Ala, Moore, Bret A., Kent Lloyd, K. C., McKerlie, Colin, Masuya, Hiroshi, Tanaka, Nobuhiko, Flicek, Paul, Parkinson, Helen E., Sedlacek, Radislav, Seong, Je Kyung, Wang, Chi-Kuang Leo, Moore, Mark, Brown, Steve D., Tschöp, Matthias H., Wurst, Wolfgang, Klingenspor, Martin, Wolf, Eckhard, Beckers, Johannes, Machicao, Fausto, Peter, Andreas, Staiger, Harald, Häring, Hans-Ulrich, Grallert, Harald, Campillos, Monica, Maier, Holger, Fuchs, Helmut, Gailus-Durner, Valerie, Werner, Thomas, Hrabe de Angelis, Martin
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2018
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5773596/
https://ncbi.nlm.nih.gov/pubmed/29348434
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-01995-2
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