A biosensor-based framework to measure latent proteostasis capacity

The pool of quality control proteins (QC) that maintains protein-folding homeostasis (proteostasis) is dynamic but can become depleted in human disease. A challenge has been in quantitatively defining the depth of the QC pool. With a new biosensor, flow cytometry-based methods and mathematical model...

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Veröffentlicht in:Nat Commun
Hauptverfasser: Wood, Rebecca J., Ormsby, Angelique R., Radwan, Mona, Cox, Dezerae, Sharma, Abhishek, Vöpel, Tobias, Ebbinghaus, Simon, Oliveberg, Mikael, Reid, Gavin E., Dickson, Alex, Hatters, Danny M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2018
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5773518/
https://ncbi.nlm.nih.gov/pubmed/29348634
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-02562-5
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