Harnessing insulin- and leptin-induced oxidation of PTP1B for therapeutic development

The protein tyrosine phosphatase PTP1B is a major regulator of glucose homeostasis and energy metabolism, and a validated target for therapeutic intervention in diabetes and obesity. Nevertheless, it is a challenging target for inhibitor development. Previously, we generated a recombinant antibody (...

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Vydáno v:Nat Commun
Hlavní autoři: Krishnan, Navasona, Bonham, Christopher A., Rus, Ioana A., Shrestha, Om Kumar, Gauss, Carla M., Haque, Aftabul, Tocilj, Ante, Joshua-Tor, Leemor, Tonks, Nicholas K.
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2018
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5773487/
https://ncbi.nlm.nih.gov/pubmed/29348454
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-02252-2
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