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Harnessing insulin- and leptin-induced oxidation of PTP1B for therapeutic development
The protein tyrosine phosphatase PTP1B is a major regulator of glucose homeostasis and energy metabolism, and a validated target for therapeutic intervention in diabetes and obesity. Nevertheless, it is a challenging target for inhibitor development. Previously, we generated a recombinant antibody (...
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| Publicado no: | Nat Commun |
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| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5773487/ https://ncbi.nlm.nih.gov/pubmed/29348454 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-02252-2 |
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