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Characterization of the impact of glutaredoxin-2 (GRX2) deficiency on superoxide/hydrogen peroxide release from cardiac and liver mitochondria

Mitochondria are critical sources of hydrogen peroxide (H(2)O(2)), an important secondary messenger in mammalian cells. Recent work has shown that O(2)(•-)/H(2)O(2) emission from individual sites of production in mitochondria is regulated by protein S-glutathionylation. Here, we conducted the first...

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Detalhes bibliográficos
Publicado no:Redox Biol
Main Authors: Chalker, Julia, Gardiner, Danielle, Kuksal, Nidhi, Mailloux, Ryan J.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5773472/
https://ncbi.nlm.nih.gov/pubmed/29274570
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.redox.2017.12.006
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