Protein S-glutathionylation lowers superoxide/hydrogen peroxide release from skeletal muscle mitochondria through modification of complex I and inhibition of pyruvate uptake

Protein S-glutathionylation is a reversible redox modification that regulates mitochondrial metabolism and reactive oxygen species (ROS) production in liver and cardiac tissue. However, whether or not it controls ROS release from skeletal muscle mitochondria has not been explored. In the present stu...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Gill, Robert M., O’Brien, Marisa, Young, Adrian, Gardiner, Danielle, Mailloux, Ryan J.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5812644/
https://ncbi.nlm.nih.gov/pubmed/29444156
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0192801
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