Protein S-glutathionylation lowers superoxide/hydrogen peroxide release from skeletal muscle mitochondria through modification of complex I and inhibition of pyruvate uptake

Protein S-glutathionylation is a reversible redox modification that regulates mitochondrial metabolism and reactive oxygen species (ROS) production in liver and cardiac tissue. However, whether or not it controls ROS release from skeletal muscle mitochondria has not been explored. In the present stu...

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Pubblicato in:PLoS One
Autori principali: Gill, Robert M., O’Brien, Marisa, Young, Adrian, Gardiner, Danielle, Mailloux, Ryan J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2018
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5812644/
https://ncbi.nlm.nih.gov/pubmed/29444156
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0192801
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