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Characterization of the impact of glutaredoxin-2 (GRX2) deficiency on superoxide/hydrogen peroxide release from cardiac and liver mitochondria

Mitochondria are critical sources of hydrogen peroxide (H(2)O(2)), an important secondary messenger in mammalian cells. Recent work has shown that O(2)(•-)/H(2)O(2) emission from individual sites of production in mitochondria is regulated by protein S-glutathionylation. Here, we conducted the first...

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Pubblicato in:Redox Biol
Autori principali: Chalker, Julia, Gardiner, Danielle, Kuksal, Nidhi, Mailloux, Ryan J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Elsevier 2017
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5773472/
https://ncbi.nlm.nih.gov/pubmed/29274570
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.redox.2017.12.006
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