The farnesoid X receptor agonist obeticholic acid upregulates biliary excretion of asymmetric dimethylarginine via MATE-1 during hepatic ischemia/reperfusion injury

BACKGROUND: We previously showed that increased asymmetric dimethylarginine (ADMA) biliary excretion occurs during hepatic ischemia/reperfusion (I/R), prompting us to study the effects of the farnesoid X receptor (FXR) agonist obeticholic acid (OCA) on bile, serum and tissue levels of ADMA after I/R...

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Veröffentlicht in:PLoS One
Hauptverfasser: Ferrigno, Andrea, Di Pasqua, Laura Giuseppina, Berardo, Clarissa, Siciliano, Veronica, Rizzo, Vittoria, Adorini, Luciano, Richelmi, Plinio, Vairetti, Mariapia
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2018
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5773219/
https://ncbi.nlm.nih.gov/pubmed/29346429
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0191430
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