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Liver plays a central role in asymmetric dimethylarginine-mediated organ injury

Asymmetric-dimethylarginine (ADMA) competes with L-arginine for each of the three isoforms of nitric oxide synthase: endothelial; neuronal; inducible. ADMA is synthesized by protein methyltransferases followed by proteolytic degradation. ADMA is metabolized to citrulline and dimethylamine, by dimeth...

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Опубликовано в: :World J Gastroenterol
Главные авторы: Ferrigno, Andrea, Di Pasqua, Laura G, Berardo, Clarissa, Richelmi, Plinio, Vairetti, Mariapia
Формат: Artigo
Язык:Inglês
Опубликовано: Baishideng Publishing Group Inc 2015
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4419053/
https://ncbi.nlm.nih.gov/pubmed/25954086
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3748/wjg.v21.i17.5131
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