The Marburgvirus-neutralizing human monoclonal antibody MR191 targets a conserved site to block virus receptor binding

Since its first identification 50 years ago, Marburgviruses have emerged several times, with 83–90% lethality in the largest outbreaks. Although no vaccines or therapeutics are available for human use, the human antibody MR191 provides complete protection in nonhuman primates when delivered several...

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Detalhes bibliográficos
Publicado no:Cell Host Microbe
Main Authors: King, Liam B., Fusco, Marnie L., Flyak, Andrew I., Ilinykh, Philipp A., Huang, Kai, Gunn, Bronwyn, Kirchdoerfer, Robert N., Hastie, Kathryn M., Sangha, Amandeep K., Meiler, Jens, Alter, Galit, Bukreyev, Alexander, Crowe, James E., Saphire, Erica Ollmann
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5772738/
https://ncbi.nlm.nih.gov/pubmed/29324225
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chom.2017.12.003
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