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α-Synuclein may cross-bridge v-SNARE and acidic phospholipids to facilitate SNARE-dependent vesicle docking

Misfolded α-synuclein (A-syn) is widely recognized as the primal cause of neurodegenerative diseases including Parkinson’s disease and dementia with Lewy bodies. The normal cellular function of A-syn has, however, been elusive. There is evidence that A-syn plays multiple roles in the exocytotic path...

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Détails bibliographiques
Publié dans:Biochem J
Auteurs principaux: Lou, Xiaochu, Kim, Jaewook, Hawk, Brenden J., Shin, Yeon-Kyun
Format: Artigo
Langue:Inglês
Publié: 2017
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5772654/
https://ncbi.nlm.nih.gov/pubmed/28495859
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BCJ20170200
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