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Mechanically-sensitive miRNAs bias human mesenchymal stem cell fate via mTOR signalling

Mechanotransduction is a strong driver of mesenchymal stem cell (MSC) fate. In vitro, variations in matrix mechanics invoke changes in MSC proliferation, migration and differentiation. However, when incorporating MSCs within injectable, inherently soft hydrogels, this dominance over MSC response sub...

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Bibliografiske detaljer
Udgivet i:Nat Commun
Main Authors: Frith, Jessica E., Kusuma, Gina D., Carthew, James, Li, Fanyi, Cloonan, Nicole, Gomez, Guillermo A., Cooper-White, Justin J.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2018
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5772625/
https://ncbi.nlm.nih.gov/pubmed/29343687
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-02486-0
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