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Mechanically-sensitive miRNAs bias human mesenchymal stem cell fate via mTOR signalling
Mechanotransduction is a strong driver of mesenchymal stem cell (MSC) fate. In vitro, variations in matrix mechanics invoke changes in MSC proliferation, migration and differentiation. However, when incorporating MSCs within injectable, inherently soft hydrogels, this dominance over MSC response sub...
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| Publicado no: | Nat Commun |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5772625/ https://ncbi.nlm.nih.gov/pubmed/29343687 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-02486-0 |
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