Metal-dependent allosteric activation and inhibition on the same molecular scaffold: the copper sensor CopY from Streptococcus pneumoniae

Resistance to copper (Cu) toxicity in the respiratory pathogen Streptococcus pneumoniae is regulated by the Cu-specific metallosensor CopY. CopY is structurally related to the antibiotic-resistance regulatory proteins MecI and BlaI from Staphylococcus aureus, but is otherwise poorly characterized. H...

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Detalhes bibliográficos
Publicado no:Chem Sci
Main Authors: Glauninger, Hendrik, Zhang, Yifan, Higgins, Khadine A., Jacobs, Alexander D., Martin, Julia E., Fu, Yue, Coyne, 3rd, H. Jerome, Bruce, Kevin E., Maroney, Michael J., Clemmer, David E., Capdevila, Daiana A., Giedroc, David P.
Formato: Artigo
Idioma:Inglês
Publicado em: Royal Society of Chemistry 2017
Assuntos:
Chemistry
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5772342/
https://ncbi.nlm.nih.gov/pubmed/29399317
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c7sc04396a
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