Oxysterol Sensing through the Receptor GPR183 Promotes the Lymphoid-Tissue-Inducing Function of Innate Lymphoid Cells and Colonic Inflammation

Group 3 innate lymphoid cells (ILC3s) sense environmental signals and are critical for tissue integrity in the intestine. Yet, which signals are sensed and what receptors control ILC3 function remain poorly understood. Here, we show that ILC3s with a lymphoid-tissue-inducer (LTi) phenotype expressed...

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Udgivet i:Immunity
Main Authors: Emgård, Johanna, Kammoun, Hana, García-Cassani, Bethania, Chesné, Julie, Parigi, Sara M., Jacob, Jean-Marie, Cheng, Hung-Wei, Evren, Elza, Das, Srustidhar, Czarnewski, Paulo, Sleiers, Natalie, Melo-Gonzalez, Felipe, Kvedaraite, Egle, Svensson, Mattias, Scandella, Elke, Hepworth, Matthew R., Huber, Samuel, Ludewig, Burkhard, Peduto, Lucie, Villablanca, Eduardo J., Veiga-Fernandes, Henrique, Pereira, João P., Flavell, Richard A., Willinger, Tim
Format: Artigo
Sprog:Inglês
Udgivet: Cell Press 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5772175/
https://ncbi.nlm.nih.gov/pubmed/29343433
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2017.11.020
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