TEM8/ANTXR1-specific CAR T cells as a targeted therapy for triple-negative breast cancer

Triple-negative breast cancer (TNBC) is an aggressive disease lacking targeted therapy. In this study, we developed a CAR T cell-based immunotherapeutic strategy to target TEM8, a marker initially defined on endothelial cells in colon tumors that was discovered recently to be upregulated in TNBC. CA...

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Bibliografiske detaljer
Udgivet i:Cancer Res
Main Authors: Byrd, Tiara T., Fousek, Kristen, Pignata, Antonella, Szot, Christopher, Samaha, Heba, Seaman, Steven, Dobrolecki, Lacey, Salsman, Vita, Oo, Htoo Zarni, Bielamowicz, Kevin, Landi, Daniel, Rainusso, Nino, Hicks, John, Powell, Suzanne, Baker, Matthew L., Wels, Winfried S., Koch, Joachim, Sorensen, Poul H., Deneen, Benjamin, Ellis, Matthew J., Lewis, Michael, Hegde, Meenakshi, Fletcher, Bradley S., St. Croix, Brad, Ahmed, Nabil
Format: Artigo
Sprog:Inglês
Udgivet: 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5771806/
https://ncbi.nlm.nih.gov/pubmed/29183891
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-16-1911
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