TEM8/ANTXR1-specific CAR T cells as a targeted therapy for triple-negative breast cancer

Triple-negative breast cancer (TNBC) is an aggressive disease lacking targeted therapy. In this study, we developed a CAR T cell-based immunotherapeutic strategy to target TEM8, a marker initially defined on endothelial cells in colon tumors that was discovered recently to be upregulated in TNBC. CA...

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Detalhes bibliográficos
Publicado no:Cancer Res
Main Authors: Byrd, Tiara T., Fousek, Kristen, Pignata, Antonella, Szot, Christopher, Samaha, Heba, Seaman, Steven, Dobrolecki, Lacey, Salsman, Vita, Oo, Htoo Zarni, Bielamowicz, Kevin, Landi, Daniel, Rainusso, Nino, Hicks, John, Powell, Suzanne, Baker, Matthew L., Wels, Winfried S., Koch, Joachim, Sorensen, Poul H., Deneen, Benjamin, Ellis, Matthew J., Lewis, Michael, Hegde, Meenakshi, Fletcher, Bradley S., St. Croix, Brad, Ahmed, Nabil
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5771806/
https://ncbi.nlm.nih.gov/pubmed/29183891
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-16-1911
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