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Absence of Carbohydrate Response Element Binding Protein in Adipocytes Causes Systemic Insulin Resistance and Impairs Glucose Transport

Lower adipose-ChREBP and de novo lipogenesis (DNL) are associated with insulin resistance in humans. Here we generated adipose-specific ChREBP knockout (AdChREBP KO) mice with negligible sucrose-induced DNL in adipose tissue (AT). Chow-fed AdChREBP KO mice are insulin-resistant with impaired insulin...

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Λεπτομέρειες βιβλιογραφικής εγγραφής
Τόπος έκδοσης:	Cell Rep
Κύριοι συγγραφείς:	Vijayakumar, Archana, Aryal, Pratik, Wen, Jennifer, Syed, Ismail, Vazirani, Reema P., Moraes-Vieira, Pedro M., Camporez, Joao Paulo, Gallop, Molly R., Perry, Rachel J., Peroni, Odile D., Shulman, Gerald I., Saghatelian, Alan, McGraw, Timothy E., Kahn, Barbara B.
Μορφή:	Artigo
Γλώσσα:	Inglês
Έκδοση:	2017
Θέματα:	Article
Διαθέσιμο Online:	https://ncbi.nlm.nih.gov/pmc/articles/PMC5771491/ https://ncbi.nlm.nih.gov/pubmed/29069585 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2017.09.091
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Absence of Carbohydrate Response Element Binding Protein in Adipocytes Causes Systemic Insulin Resistance and Impairs Glucose Transport

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