A single nucleotide polymorphism in CYP1B1 leads to differential prostate cancer risk and telomere length

BACKGROUND: Cytochrome P450 1B1 (CYP1B1) is a key enzyme in its oestrogen metabolism pathway, giving rise to hydroxylation and conjugation. Functionally relevant genetic variants within CYP1B1 may affect the telomere length and subsequently lead to prostate carcinogenesis. METHODS: We evaluated 8 CY...

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Veröffentlicht in:J Cancer
Hauptverfasser: Gu, Cheng-Yuan, Li, Gao-Xiang, Zhu, Yu, Xu, Hua, Zhu, Yao, Qin, Xiao-Jian, Bo, Dai, Ye, Ding-Wei
Format: Artigo
Sprache:Inglês
Veröffentlicht: Ivyspring International Publisher 2018
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Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5771334/
https://ncbi.nlm.nih.gov/pubmed/29344273
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/jca.21774
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