Dual NAMPT and BTK Targeting Leads to Synergistic Killing of Waldenstrom's Macroglobulinemia Cells Regardless of MYD88 and CXCR4 Somatic Mutations Status

PURPOSE: Nicotinamide phosphoribosyltransferase (Nampt) regulates intracellular NAD(+) pool and is highly expressed in a number of malignancies. FK866, a selective inhibitor of Nampt, depletes intracellular NAD(+) levels, thereby blocking cellular metabolism and triggering sensitization to other dru...

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Pubblicato in:Clin Cancer Res
Autori principali: Cea, Michele, Cagnetta, Antonia, Acharya, Chirag, Acharya, Prakrati, Tai, Yu-Tzu, Yang, Guang, Lovera, Davide, Soncini, Debora, Miglino, Maurizio, Fraternali-Orcioni, Giulio, Mastracci, Luca, Nencioni, Alessio, Montecucco, Fabrizio, Ballestrero, Alberto, Hideshima, Teru, Chauhan, Dharminder, Gobbi, Marco, Lemoli, Roberto M., Munshi, Nikhil, Treon, Steven P., Anderson, Kenneth C.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2016
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5771267/
https://ncbi.nlm.nih.gov/pubmed/27287071
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-16-0630
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