Interaction of Monomeric Interleukin-8 with CXCR1 Mapped by Proton-Detected Fast MAS Solid-State NMR

The human chemokine interleukin-8 (IL-8; CXCL8) is a key mediator of innate immune and inflammatory responses. This small, soluble protein triggers a host of biological effects upon binding and activating CXCR1, a G protein-coupled receptor, located in the cell membrane of neutrophils. Here, we desc...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:Biophys J
Hauptverfasser: Park, Sang Ho, Berkamp, Sabrina, Radoicic, Jasmina, De Angelis, Anna A., Opella, Stanley J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: The Biophysical Society 2017
Schlagworte:
Proteins
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5771212/
https://ncbi.nlm.nih.gov/pubmed/29262362
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2017.09.041
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