Bioactivity of the putative apelin proprotein expands the repertoire of apelin receptor ligands

BACKGROUND: Apelin is a peptide ligand for a class A G-protein coupled receptor called the apelin receptor (AR or APJ) that regulates angiogenesis, the adipoinsular axis, and cardiovascular functions. Apelin has been shown to be bioactive as 13, 17, and 36 amino acid isoforms, C-terminal fragments o...

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Publicado en:Biochim Biophys Acta
Autores principales: Shin, Kyungsoo, Chapman, Nigel A., Sarker, Muzaddid, Kenward, Calem A., Huang, Shuya K., Weatherbee-Martin, Nathan, Pandey, Aditya, Dupré, Denis J., Rainey, Jan K.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2017
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5770203/
https://ncbi.nlm.nih.gov/pubmed/28546009
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbagen.2017.05.017
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