Bioactivity of the putative apelin proprotein expands the repertoire of apelin receptor ligands

BACKGROUND: Apelin is a peptide ligand for a class A G-protein coupled receptor called the apelin receptor (AR or APJ) that regulates angiogenesis, the adipoinsular axis, and cardiovascular functions. Apelin has been shown to be bioactive as 13, 17, and 36 amino acid isoforms, C-terminal fragments o...

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Bibliographic Details
Published in:Biochim Biophys Acta
Main Authors: Shin, Kyungsoo, Chapman, Nigel A., Sarker, Muzaddid, Kenward, Calem A., Huang, Shuya K., Weatherbee-Martin, Nathan, Pandey, Aditya, Dupré, Denis J., Rainey, Jan K.
Format: Artigo
Language:Inglês
Published: 2017
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5770203/
https://ncbi.nlm.nih.gov/pubmed/28546009
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbagen.2017.05.017
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