Apelin conformational and binding equilibria upon micelle interaction primarily depend on membrane-mimetic headgroup

Apelin is one of two peptide hormones that activate the apelin receptor (AR or APJ) to regulate the cardiovascular system, central nervous system, and adipoinsular axis. Here, we apply circular dichroism (CD) spectropolarimetry and nuclear magnetic resonance (NMR) spectroscopy to characterize the po...

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Bibliographic Details
Published in:Sci Rep
Main Authors: Shin, Kyungsoo, Sarker, Muzaddid, Huang, Shuya K., Rainey, Jan K.
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2017
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5684411/
https://ncbi.nlm.nih.gov/pubmed/29133807
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-14784-0
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