Activation of G protein-coupled estrogen receptor signaling inhibits melanoma and improves response to immune checkpoint blockade

Female sex and history of prior pregnancies are associated with favorable melanoma outcomes. Here, we show that much of the melanoma protective effect likely results from estrogen signaling through the G protein-coupled estrogen receptor (GPER) on melanocytes. Selective GPER activation in primary me...

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Udgivet i:eLife
Main Authors: Natale, Christopher A, Li, Jinyang, Zhang, Junqian, Dahal, Ankit, Dentchev, Tzvete, Stanger, Ben Z, Ridky, Todd W
Format: Artigo
Sprog:Inglês
Udgivet: eLife Sciences Publications, Ltd 2018
Fag:
Cancer Biology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5770157/
https://ncbi.nlm.nih.gov/pubmed/29336307
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.31770
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