Pharmacologic Activation of the G Protein–Coupled Estrogen Receptor Inhibits Pancreatic Ductal Adenocarcinoma

BACKGROUND & AIMS: Female sex is associated with lower incidence and improved clinical outcomes for most cancer types including pancreatic ductal adenocarcinoma (PDAC). The mechanistic basis for this sex difference is unknown. We hypothesized that estrogen signaling may be responsible, despite t...

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Vydáno v:Cell Mol Gastroenterol Hepatol
Hlavní autoři: Natale, Christopher A., Li, Jinyang, Pitarresi, Jason R., Norgard, Robert J., Dentchev, Tzvete, Capell, Brian C., Seykora, John T., Stanger, Ben Z., Ridky, Todd W.
Médium: Artigo
Jazyk:Inglês
Vydáno: Elsevier 2020
Témata:
Original Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7578406/
https://ncbi.nlm.nih.gov/pubmed/32376419
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jcmgh.2020.04.016
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