Pharmacologic Activation of the G Protein–Coupled Estrogen Receptor Inhibits Pancreatic Ductal Adenocarcinoma

BACKGROUND & AIMS: Female sex is associated with lower incidence and improved clinical outcomes for most cancer types including pancreatic ductal adenocarcinoma (PDAC). The mechanistic basis for this sex difference is unknown. We hypothesized that estrogen signaling may be responsible, despite t...

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Detalles Bibliográficos
Publicado en:Cell Mol Gastroenterol Hepatol
Main Authors: Natale, Christopher A., Li, Jinyang, Pitarresi, Jason R., Norgard, Robert J., Dentchev, Tzvete, Capell, Brian C., Seykora, John T., Stanger, Ben Z., Ridky, Todd W.
Formato: Artigo
Idioma:Inglês
Publicado: Elsevier 2020
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Original Research
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7578406/
https://ncbi.nlm.nih.gov/pubmed/32376419
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jcmgh.2020.04.016
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