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Hydrophobic Effect from Conjugated Chemicals or Drugs on In Vivo Biodistribution of RNA Nanoparticles

Liver or other organ accumulation of drugs is one of the major problems that leads to toxicity and side effects in therapy using chemicals or other macromolecules. It has been shown that specially designed RNA nanoparticles can specifically target cancer cells, silence oncogenic genes, and stop canc...

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Pubblicato in:Hum Gene Ther
Autori principali: Jasinski, Daniel L., Yin, Hongran, Li, Zhefeng, Guo, Peixuan
Natura: Artigo
Lingua:Inglês
Pubblicazione: Mary Ann Liebert, Inc. 2018
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5770098/
https://ncbi.nlm.nih.gov/pubmed/28557574
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/hum.2017.054
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