Evaluation of Intrathecal Routes of Administration for Adeno-Associated Viral Vectors in Large Animals

Delivery of adeno-associated viral (AAV) vectors into the cerebrospinal fluid (CSF) can achieve gene transfer to cells throughout the brain and spinal cord, potentially making many neurological diseases tractable gene therapy targets. Identifying the optimal route of CSF access for intrathecal AAV d...

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Dades bibliogràfiques
Publicat a:Hum Gene Ther
Autors principals: Hinderer, Christian, Bell, Peter, Katz, Nathan, Vite, Charles H., Louboutin, Jean-Pierre, Bote, Erin, Yu, Hongwei, Zhu, Yanqing, Casal, Margret L., Bagel, Jessica, O'Donnell, Patricia, Wang, Ping, Haskins, Mark E., Goode, Tamara, Wilson, James M.
Format: Artigo
Idioma:Inglês
Publicat: Mary Ann Liebert, Inc. 2018
Matèries:
Research Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5770082/
https://ncbi.nlm.nih.gov/pubmed/28806897
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/hum.2017.026
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