Cocaine and HIV-1 Tat Disrupt Cholesterol Homeostasis in Astrocytes: Implications for HIV-Associated Neurocognitive Disorders in Cocaine User Patients

Cholesterol synthesis and clearance by astrocytes are tightly regulated to maintain constant levels within the brain. In this context, liver X receptors (LXRs) are the master regulators of cholesterol homeostasis in the central nervous system (CNS). Increasing levels of cholesterol in astrocytes tri...

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Publicado en:Glia
Autores principales: Cotto, Bianca, Natarajaseenivasan, Kalimuthusamy, Ferrero, Kimberly, Wesley, Leroy, Sayre, Matthew, Langford, Dianne
Formato: Artigo
Lenguaje:Inglês
Publicado: 2018
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5769965/
https://ncbi.nlm.nih.gov/pubmed/29330881
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/glia.23291
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