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A Drosophila model of insulin resistance associated with the human TRIB3 Q/R polymorphism
Members of the Tribbles family of proteins are conserved pseudokinases with diverse roles in cell growth and proliferation. Both Drosophila Tribbles (Trbl) and vertebrate Trib3 proteins bind to the kinase Akt (Akt1) to block its phosphorylation activation and reduce downstream insulin-stimulated ana...
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| Publicat a: | Dis Model Mech |
|---|---|
| Autors principals: | , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
The Company of Biologists Ltd
2017
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5769606/ https://ncbi.nlm.nih.gov/pubmed/29025897 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dmm.030619 |
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