A Drosophila model of insulin resistance associated with the human TRIB3 Q/R polymorphism

Members of the Tribbles family of proteins are conserved pseudokinases with diverse roles in cell growth and proliferation. Both Drosophila Tribbles (Trbl) and vertebrate Trib3 proteins bind to the kinase Akt (Akt1) to block its phosphorylation activation and reduce downstream insulin-stimulated ana...

Full description

Saved in:
Bibliographic Details
Published in:Dis Model Mech
Main Authors: Fischer, Zachary, Das, Rahul, Shipman, Anna, Fan, Jin-Yuan, Pence, Laramie, Bouyain, Samuel, Dobens, Leonard L.
Format: Artigo
Language:Inglês
Published: The Company of Biologists Ltd 2017
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5769606/
https://ncbi.nlm.nih.gov/pubmed/29025897
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dmm.030619
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items