Modulating the metabolism by trimetazidine enhances myoblast differentiation and promotes myogenesis in cachectic tumor-bearing c26 mice

Trimetazidine (TMZ) is a metabolic reprogramming agent able to partially inhibit mitochondrial free fatty acid β-oxidation while enhancing glucose oxidation. Here we have found that the metabolic shift driven by TMZ enhances the myogenic potential of skeletal muscle progenitor cells leading to MyoD,...

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Vydáno v:Oncotarget
Hlavní autoři: Gatta, Lucia, Vitiello, Laura, Gorini, Stefania, Chiandotto, Sergio, Costelli, Paola, Giammarioli, Anna Maria, Malorni, Walter, Rosano, Giuseppe, Ferraro, Elisabetta
Médium: Artigo
Jazyk:Inglês
Vydáno: Impact Journals LLC 2017
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5768376/
https://ncbi.nlm.nih.gov/pubmed/29371959
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.23044
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