The mitochondrial metabolic reprogramming agent trimetazidine as an ‘exercise mimetic’ in cachectic C26‐bearing mice

BACKGROUND: Cancer cachexia is characterized by muscle depletion and exercise intolerance caused by an imbalance between protein synthesis and degradation and by impaired myogenesis. Myofibre metabolic efficiency is crucial so as to assure optimal muscle function. Some drugs are able to reprogram ce...

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Bibliografiska uppgifter
I publikationen:J Cachexia Sarcopenia Muscle
Huvudupphovsmän: Molinari, Francesca, Pin, Fabrizio, Gorini, Stefania, Chiandotto, Sergio, Pontecorvo, Laura, Penna, Fabio, Rizzuto, Emanuele, Pisu, Simona, Musarò, Antonio, Costelli, Paola, Rosano, Giuseppe, Ferraro, Elisabetta
Materialtyp: Artigo
Språk:Inglês
Publicerad: John Wiley and Sons Inc. 2017
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Original Articles
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5700442/
https://ncbi.nlm.nih.gov/pubmed/29130633
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcsm.12226
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