Targeting the PTTG1 oncogene impairs proliferation and invasiveness of melanoma cells sensitive or with acquired resistance to the BRAF inhibitor dabrafenib

The pituitary tumor transforming gene 1 (PTTG1) is implicated in tumor growth, metastasis and drug resistance. Here, we investigated the involvement of PTTG1 in melanoma cell proliferation, invasiveness and response to the BRAF inhibitor (BRAFi) dabrafenib. We also preliminary assessed the potential...

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Vydáno v:Oncotarget
Hlavní autoři: Caporali, Simona, Alvino, Ester, Lacal, Pedro Miguel, Ruffini, Federica, Levati, Lauretta, Bonmassar, Laura, Scoppola, Alessandro, Marchetti, Paolo, Mastroeni, Simona, Antonini Cappellini, Gian Carlo, D’Atri, Stefania
Médium: Artigo
Jazyk:Inglês
Vydáno: Impact Journals LLC 2017
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5768340/
https://ncbi.nlm.nih.gov/pubmed/29371923
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.23052
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