Targeting the PTTG1 oncogene impairs proliferation and invasiveness of melanoma cells sensitive or with acquired resistance to the BRAF inhibitor dabrafenib

The pituitary tumor transforming gene 1 (PTTG1) is implicated in tumor growth, metastasis and drug resistance. Here, we investigated the involvement of PTTG1 in melanoma cell proliferation, invasiveness and response to the BRAF inhibitor (BRAFi) dabrafenib. We also preliminary assessed the potential...

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Dettagli Bibliografici
Pubblicato in:Oncotarget
Autori principali: Caporali, Simona, Alvino, Ester, Lacal, Pedro Miguel, Ruffini, Federica, Levati, Lauretta, Bonmassar, Laura, Scoppola, Alessandro, Marchetti, Paolo, Mastroeni, Simona, Antonini Cappellini, Gian Carlo, D’Atri, Stefania
Natura: Artigo
Lingua:Inglês
Pubblicazione: Impact Journals LLC 2017
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Research Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5768340/
https://ncbi.nlm.nih.gov/pubmed/29371923
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.23052
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